Both Trioxidil and Minoxidil are topical solutions designed to address hair loss, and they have many similarities in terms of their goals—to promote hair growth and prevent further hair loss. However, they contain different active ingredients.

Minoxidil is a well-established and widely used over-the-counter medication for hair loss. It is believed to work by dilating blood vessels in the scalp, improving blood flow to the hair follicles and promoting hair growth.

On the other hand, Trioxidil is a frug-free proprietary complex developed by FOLIGAIN®. It is designed to be a triple-action nutrient complex infused with natural and bioactive ingredients to support scalp health and reduce hair loss.

Yes! Trioxidil can be used be used with FOLIGAIN Minoxidil 5% and 2%

Minoxidil has undergone extensive research, initially as a vasodilator for hypertension and later as a topical solution for hair loss. Clinical trials, such as those published in the Journal of the American Academy of Dermatology, demonstrated its efficacy in promoting hair regrowth and slowing hair loss. Long-term studies, including a five-year clinical trial published in the Journal of the European Academy of Dermatology and Venereology, have provided insights into sustained effectiveness. Comparative studies and investigations into minoxidil's molecular mechanisms and patient satisfaction have also contributed to the understanding of its use in treating hair loss. While widely accepted, individual responses may vary, and consulting healthcare professionals is recommended for a comprehensive understanding of its applications and outcomes.

Minoxidil is generally considered safe when used according to prescribed guidelines for treating hair loss. Common side effects include mild scalp irritation or itching, and less frequently, allergic reactions or unwanted hair growth in adjacent areas. It can be systemically absorbed through the skin, particularly with oral use, potentially leading to blood pressure-related side effects. It is essential to adhere to recommended dosages and application instructions, avoiding excessive use. Individuals with underlying health conditions or those taking other medications should consult with a healthcare professional before starting minoxidil. Pregnant or breastfeeding individuals should also seek advice from a healthcare provider. While generally well-tolerated, any unexpected side effects or concerns should prompt consultation with a healthcare professional for personalized guidance.

Shedding, in the context of using hair regrowth products, refers to a temporary increase in hair loss that some individuals may experience when they begin a new hair treatment regimen. This phenomenon is often known as "shedding" or "shedding phase." It can be a cause of concern for those using hair regrowth products, but it is generally considered a normal part of the hair growth cycle and the body's response to the introduction of a new treatment.

Here's an explanation of shedding in the context of hair regrowth products:

1. Transition Period: When individuals start using certain hair regrowth products, especially those containing active ingredients like Minoxidil or other growth stimulants, the hair follicles may go through a transition period.
   
2. Stimulation of Dormant Follicles: Hair regrowth products often work by stimulating hair follicles to transition from a resting (telogen) phase to an active growth (anagen) phase. This stimulation can cause existing hairs in the telogen phase to be shed as new, healthier hairs begin to grow.
   
3. Normal Part of the Process: Shedding is a natural part of the hair growth cycle. It doesn't mean the product isn't working; instead, it indicates that the hair follicles are responding to the treatment and making way for new, potentially thicker and healthier strands.
   
4. Temporary: Shedding is usually temporary, and it may last for a few weeks. It is essential to differentiate between normal shedding and prolonged or excessive hair loss, which may be a sign of an underlying issue.
   
5. Consultation with a Professional: If shedding persists or if there are concerns about hair loss, it's advisable to consult with a dermatologist or healthcare professional. They can assess whether the shedding is within normal limits or if any adjustments to the treatment regimen are necessary.

It's important for individuals using hair regrowth products to be patient and give the treatment time to show its effects. If there are concerns about shedding or overall hair health, seeking guidance from a healthcare professional can provide valuable insights and reassurance.

Given the nature of hair loss, it's crucial to maintain continuous use of the treatment to preserve the achieved results. It's essential to recognize that any hair loss treatment, including this one, is a form of ongoing management.

The only way to persistently address hair loss is by consistently using the treatment. Discontinuing the treatment will likely lead to a gradual return to the level of hair loss you would have experienced if you had never used any intervention.